When trying to diagnose male factor fertility, the patient’s complete medical history is recorded and physical examination undertaken. Semen analysis is conducted, with the semen specimens collected and examined for various factors, such as count, motility, morphology, volume, consistency, and pH. Other tests could be ordered to check for hormonal imbalance (i.e. testosterone, FSH, LH, etc.), and also for genetic defects.

To diagnose structural problems, a fructose test could be ordered to check for structural blockage of the seminal vesicles. The absence of fructose in the semen could indicate a structural problem.